Innovative aptamer cream shows promise in treating allergic contact dermatitis in mice

University of BonnJul 4 2024 What is known as an aptamer binds to certain immune system messenger substances, rendering them ineffective. This even works if the active ingredient is applied to the skin in the form of an ointment. The working groups involved hope that aptamer creams such as this could also be suitable for treating other skin conditions. The results have now been published in the journal Molecular Therapies - Nucleic Acids.

Fishing in the aptamer library "Today, it is relatively easy to produce huge libraries of aptamers, the sequence of which differs at random," explains Prof. Dr. Günter Mayer from the LIMES Institute at the University of Bonn. "Some of these libraries contain millions more potential active ingredients than there are people alive on Earth."

CCL22 then attracts T cells, which migrate to the site of the action. The result is an allergic reaction.

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