TIMP-1 protein found to boost immune system's fight against cancer

University of TurkuJun 14 2024 They discovered that TIMP-1, a protein traditionally known to prevent damage to the body's cells and tissues, plays a critical role in the immune system's defense against cancer. The findings of the study could improve the effectiveness of current cancer immunotherapies.

For patients deficient in TIMP-1 expression, our discovery helps create rational therapeutic innovations." According to Figueiredo, the new findings are also relevant for fighting infections by viruses and bacteria, as the process is part of a universal mechanism that fights microorganisms and cancer in a similar fashion.

Related Stories"The published research shows how the reverse translational method works in practice. Traditional translational research typically starts with basic laboratory discoveries, which are later tested on patients in clinical trials. The reverse translational approach, on the other hand, starts with real-world data from patient samples to guide focused laboratory studies, thereby enhancing the likelihood of success when applied to patients," explains Figueiredo.

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