Reviewed by Megan Craig, M.Sc.Sep 13 2023 Their study sheds new light on the protein called 'TonEBP,' revealing its significant role in the development of lupus and lupus nephritis. This breakthrough not only enhances our understanding of these conditions, but also opens up potential avenues for future treatment options.
The findings unveiled elevated expression levels of TonEBP not only within kidney cells but also infiltrating immune cells when compared to control patients. This increased expression correlated with inflammatory cytokines involved in inflammatory reactions triggered by bacterial or viral infections, as well as severity of proteinuria-;a key indicator reflecting kidney damage.
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