NK cells at a comprehensive pan-cancer level for the first time. These subtypes were meticulously characterized for their phenotypic and functional diversity.
Through the integration of this extensive dataset, the researchers observed a preference of NK cell subtype composition across different cancer types. Notably, the distribution of NK cell subtypes within tumors, neighboring tissues and peripheral blood displayed significant disparities. Leveraging advanced bioinformatics techniques, the researchers pinpointed the gene RGS1 as being highly expressed in non-blood NK cells. At transcriptional level, RGS1 demonstrated remarkable specificity and sensitivity, compared to conventional tissue residency markers.
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