New test could detect brain tumors using cerebrospinal fluid

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Researchers with the Johns Hopkins Kimmel Cancer Center, the Johns Hopkins University School of Medicine and four other institutions have developed a molecular test to identify the presence of brain tumors by measuring abnormal genetic material shed by tumors and circulating in cerebrospinal fluid (CSF).

Reviewed by Lily Ramsey, LLMSep 7 2023 A description of the work was published Aug. 15 in the journal Cell Reports Medicine.

In laboratory evaluations of the test in 280 CSF samples from patients, some with brain or other cancers and some without cancer, Real-CSF correctly identified 67% of 184 cancerous brain lesions and 96% of 96 noncancerous lesions. This analysis was more likely to correctly identify cancers than the standard of care, cytology. Of 121 patients with cancer in whom cytology results were available, only 28 were detected by cytology, whereas Real-CSF correctly detected 69% of cancers in this group.

 

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