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Researchers identify new gene mutation that alters Alzheimer's disease risk

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A study led by experts from Indiana University School of Medicine has shed new light on the genetic underpinnings of Alzheimer's disease. The team's research, rooted in human genetics studies, has unearthed a critical mutation within a key gene operating in the brain's immune cells, potentially elevating the risk of Alzheimer's disease.

behind the research, encompassing his Ph.D. thesis. Tsai, now a postdoctoral fellow at Stanford University Medical School, has significantly contributed to unraveling the mysteries of Alzheimer's disease.

Innovative mouse models of Alzheimer's disease developed by the MODEL-AD Center allowed researchers to substantiate their findings. Immune cells harboring risk-reducing gene variants demonstrated a reduction in amyloid plaques, while those carrying the risk-elevating variants exhibited a surge in plaque accumulation. The study unveiled specific gene clusters orchestrating these alterations in immune cell behavior within microglia.

 

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Researchers uncover new genetic traits influencing Alzheimer's riskResearchers at the University of Pittsburgh analyzed thousands of human genomes to find new gene variations responsible for controlling the levels of blood plasma molecules linked to Alzheimer's disease risk. The findings, published recently in Molecular Psychiatry, could contribute to the future development of simple blood tests for the disease.
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