New kidney function equation may reduce health disparities, improve access to heart failure therapy

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Physician-scientists from the University of Alabama at Birmingham Marnix E. Heersink School of Medicine recently conducted a large-scale analysis to assess the impact of a newly introduced equation used to evaluate one's heart failure risk. The study, published in the Journal of Cardiac Failure, showed that the new and old kidney function equations had comparable values in predicting the risk of heart failure.

"In an attempt to reduce these disparities, the National Kidney Foundation introduced the race-independent equation to estimate kidney function," Shetty said."This race-free equation uses the levels of two substances to estimate kidney function and was shown to be more accurate than the previous equation."

Heart failure affects about 6.2 million adults in the United States and costs the nation approximately $30.7 billion for, medications and missed days of work, according to the Centers for Disease Control and Prevention. Poor kidney function is known to be a risk factor of heart failure. Shetty and his team analyzed data from approximately 16,000 individuals of two large prospective U.S.

Shetty and his team showed that both kidney function equations were comparable in their ability to predict the risk of developing heart failure. The new kidney function equation has been deemed more accurate at estimating kidney function in Black individuals than the old equation. "Several lifesaving drugs that reduce the risk of death from heart failure require kidney function to be adequate to administer the medication safely," said Pankaj Arora, M.D., the senior author of the manuscript, an associate professor in the UAB Division of Cardiovascular Disease and cardiologist at the UAB Cardiovascular Institute.

 

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