Arterial stiffness may cause and worsen heart damage among adolescents

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Arterial stiffness is a novel cause of premature heart damage among adolescents, according to a new follow-up study. The study was conducted in collaboration between Texas Children's Hospital and Baylor College of Medicine in the U.S., the University of Bristol in the U.K., the University of Exeter in the U.K., and the University of Eastern Finland. The results were published in Atherosclerosis.

, socio-economic status, and family history of cardiovascular disease, and using adults' cut points for diagnosing heart damage, it was observed that adolescents in the highest tertial category of arterial stiffness and carotid intima-media thickness had a 23%–27% increased risk of progressively worsening structural heart damage.

Only arterial stiffness appears to independently cause both structural and functional heart damage, whereas increased carotid wall thickness does not seem to have a causal role. Increased carotid wall thickness is an early indicator of atherosclerosis, whereas increased arterial stiffness describes arteriosclerosis. The study further reported that arterial stiffness caused heart damage by increasing blood pressure and insulin resistance.

"We are seeing for the first time that arterial stiffness is a novel cause of several diseases such as hypertension, insulin resistance, metabolic syndrome, and heart damage in the young population. Among adults, arterial stiffness is currently being established as a cause of type 2 diabetes. We discovered that approximately 50% of the deleterious role of arterial stiffness in causing heart damage is enhanced by the mechanism of increased blood pressure and insulin resistance.

"Thus, preventing and lowering blood pressure and insulin resistance may potentially diminish the negative impact of arterial stiffness on the heart, by up to half," says Andrew Agbaje, a physician and clinical epidemiologist at the University of Eastern Finland. "Experimental and clinical intervention studies are urgently needed on comprehensive approaches to treating and reversing

 

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