In February, the University of Cape Town announced that a group of its researchers was expected to start a phase 1 clinical trial of an experimental Covid-19 vaccine produced by the US company ImmunityBio.
“The purpose of that was to assess safety, so participants were followed up very carefully for side effects and for reactions to the vaccine. And the review of that suggests no major safety concerns,” he says.He adds that the phase I trial design has since been adapted to include four more cohorts. This has been approved by the South African Health Products Regulatory Authority , but the UCT ethics committee still needs to approve this before they can continue.
The trial will continue at the Khayelitsha clinical research site, with participants and volunteers coming from across Cape Town. “[It] is used as the receptor binder. It’s like a lock and key mechanism that binds on your own cells ... It binds to that, locks in, and actually infects the cells,” Vardas explains.
The nucleocapsid, Meintjes says, is found on the inside of the virus and is involved in the packing of its genetic material. So far the nucleocapsid of the SARS-CoV-2 virus appears to be less prone to mutation and remains more stable over time. “What scientists do is they take these adenoviruses and they rip out their guts, they rip out the dangerous parts of them,” he says. “And they replace that with the parts of the virus that you want the immune system to see, so the parts of the coronavirus that you want the immune system to see ... [then] the immune response that you develop is against that [part of the virus].”
USA company testing its vaccines in RSA and if it works, we will be the last people to get it. Why are we the testing ground for these vaccines?!
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Source: City_Press - 🏆 7. / 72 Read more »