ERC Advanced Grant aids study on ubiquitin in DNA repair and genome stability

Johannes Gutenberg University MainzJun 28 2024 Professor Helle Ulrich, Executive Director of the Institute of Molecular Biology and professor at Johannes Gutenberg University Mainz , has been awarded an Advanced Grant from the European Research Council . She will receive EUR 2.5 million over the next five years to support her research on how a small regulatory protein called ubiquitin contributes to DNA repair and the maintenance of genome stability.

Our project builds on a powerful technique we recently developed in our lab to manipulate and target the attachment of ubiquitin to proteins in cells. By purposefully directing the ubiquitylation of a relevant target protein, such as a DNA repair factor, we can watch its effects in isolation from other cellular processes and thereby gain a deeper mechanistic understanding of its function."

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