Solid tumors are notoriously difficult to suppress. They survive and thrive in the body despite best efforts to control them—resisting even the latest immunotherapies such as PD-1 and PD-L1 targeting checkpoint inhibitors. One of the ways researchers are trying to address this problem is by disarming the tumor’s defenses against the immune system. This article describes one such effort: a novel antibody that could reinvigorate antitumor responses in patients with treatment-resistant tumors.
The highly specific binding also helps ensure the costimulatory receptor activation occurs primarily in the tumor microenviornment where PD-L1 checkpoints are expressed. This should reduce the risk of systemic immune activation and potential unwanted effects.to PD-L1 checkpoints on tumor cells, while the other two bind to 4-1BB co-stimulatory receptors on T cells. The primary purpose of the trial was to determine the safety and dosing of the experimental antibody.
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