TRPC5 gene identified as a diagnostic marker of obesity and postpartum depression

Baylor College of MedicineJul 2 2024

Dr. Sadaf Farooqi, co-corresponding author, professor of metabolism and medicine at the University of Cambridge In the current study, the Xu lab and the Farooqi lab collaborated to investigate the role of TRPC5 in obesity and postpartum depression. By combining the individual expertise of each lab – basic and genetic animal studies in the Xu lab and human genetics and clinical studies in the Farooqi lab – the team was able to show that TRPC5 is an important regulator of obesity, postpartum depression and other human behaviors.

Related StoriesDigging deeper into the mechanisms mediating the actions of this gene, the researchers found that the gene's actions seem to involve at least two different types of brain cells, Pomc neurons and oxytocin neurons, both in the hypothalamus.

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