Researchers discover role of particular protein in the development of lupus

Pohang University of Science & Technology Jul 1 2024 A research team of Professor Yoontae Lee and Jiho Park, a PhD candidate, from the Department of Life Sciences at Pohang University of Science and Technology recently discovered that a particular protein promotes the development of systemic lupus erythematosus .

SLE, one of the most prevalent autoimmune diseases, is marked by a butterfly-shaped red rash and arthritis that primarily affects the nose and cheeks. The symptoms and affected immune cells vary from patient to patient, and the cause and the underlying mechanisms are not clearly understood, complicating the provision of personalized treatment.

As a result, autoimmune symptoms such as autoantibody concentrations, immune cell infiltration into body tissues, and renal glomerulonephritis, and the development of TFH cells were reduced in the ETV5-deficient SLE mouse model. The team discovered that ETV5 enhances the expression of its target protein, osteopontin which in turn activates the AKT protein, leading to the differentiation into TFH cells.

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