Umeå UniversityJul 1 2024 A study at Umeå University, Sweden, provides new clues in the understanding of how antibiotic resistance spreads. The study shows how an enzyme breaks down the bacteria's protective outer layer, the cell wall, and thus facilitates the transfer of genes for resistance to antibiotics.
An important part of T4SS is the enzyme PrgK, which breaks down the bacterial cell wall and thus facilitates the transfer of properties between bacteria. This enzyme has three parts or domains, LytM, SLT, and CHAP. Related StoriesThe researchers also identified that another T4SS protein, PrgL, binds to PrgK and ensures that it ends up in the right place in the protein machinery.
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