Oghogho Ebeigbe, a Nigerian scientist and research associate at the Center for Gene Regulation in Health and Diseases at Cleveland State University, USA, is at the forefront of molecular biology research. His research focuses on the interplay between diet, circadian rhythms, and cell metabolism.
In an interview, Oghogho underscores the essential role of proper dieting in managing metabolic syndrome — a cluster of conditions that significantly heightens the risk of heart disease, stroke, and diabetes. Recognized for his expertise in calorie restriction diets, Ebeigbe highlights their well-documented longevity promoting benefits and effectiveness in preventing metabolic diseases. He also delves into circadian clocks, the internal timing systems that align our biological activities with the day-night cycle. Circadian misaligned individuals, such as shift workers, are prone to various health disorders. He also studies metabolism – chemical reactions that change food into energy.
“My colleagues and I have discovered a tight association between the calorie restriction diet and the circadian clock,” Ebeigbe explains. “Circadian clock disruption, either by genetic manipulation or misaligned feeding, impairs metabolism and the longevity benefits of the calorie restriction diet. Irregular food timing misaligns circadian clocks and affects major metabolic pathways needed for cellular homeostasis.