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A Deeper Look at Anti-PD-1/PD-L1 Checkpoint Inhibitors for Cancer

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PD-1 Checkpoint Protein News

PD-L1 Checkpoint Protein,Checkpoint Inhibitors,Cancer Treatment

I am a scientist, businessman, author, and philanthropist. For nearly two decades, I was a professor at Harvard Medical School and Harvard School of Public Health where I founded two academic research departments, the Division of Biochemical Pharmacology and the Division of Human Retrovirology.

I described pembrolizumab, a PD-1 targeting checkpoint inhibitor, in some detail. Since its launch, several companies have introduced antibodies targeting the same receptor. This article summarizes some of these recent advances and how they work.When many cancers advance, spread and reoccur, checkpoint inhibitors can help keep difficult tumors at bay.

One key immune checkpoint is known as PD-1, or Programmed Cell Death Protein-1. This receptor is found on the surface of T cells and other immune cells. These proteins protect the body from overly strong immune responses andWhen PD-1 binds to its partner receptors on other cells, PD-L1 or PD-L2, it sends a signal to the T cell to paralyze its normal immune function.The immune system is equipped to suppress tumors on a small scale.

 

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