New technique brings frozen brain tissue back to life without harm

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Fudan University scientists discover a method to freeze and thaw human brain tissue, retaining its functionality.

Researchers at China’s Fudan University have developed a technique that can revive human’s frozen brains without damaging them. Medical researchers at the university’s National Children’s Medical Center successfully froze and thawed brain tissue, and later, it functioned normally.

They later tested the solution under various conditions to observe the extent to which it could prevent damage. The researchers then allowed the organoids to resume growing after they were thawed for up to 150 days. The researchers observed minimal differences between organoids that had been frozen and those that had not, even in organoids frozen for as long as 18 months, according totranscriptomic analysis shows that MEDY can protect synaptic function and inhibit the endoplasmic reticulum-mediated apoptosis pathway.

The solution is developed by Dr Zhicheng Shao and his colleagues at Fudan University in Shanghai, China.

 

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