Study reveals no survival benefit from systemic therapy in very advanced solid tumors

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Patients with very advanced solid tumors saw no significant improvement in overall survival after receiving systemic therapy, according to a study published today in JAMA Oncology by researchers at The University of Texas MD Anderson Cancer Center and Yale Cancer Center.

May 17 2024University of Texas M. D. Anderson Cancer Center

Our study highlights the importance of open and honest communication about prognosis between providers and patients. Our findings may help oncologists reconsider treatment and instead provide patients with transparent information on supportive care options so they are able to make informed decisions." Adelson and colleagues analyzed de-identified data from more than 78,000 adult patients treated at 144 community oncology practices and academic/research centers.

Related Stories"A large body of research has shown that goals-of-care conversations are critical to ensuring patients receive care in line with their prognosis and personal goals. This is even more critical when we know additional therapy will not improve a patient's survival, but only cause toxicity and harm," Adelson said.

 

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