Boston, Massachusetts (US) job with Boston Children’s Hospital-Ozcan Lab

Two postdoctoral positions are available in the Ozcan Laboratory in the Division of Endocrinology, Boston Children’s Hospital, Harvard Medical School.

The positions are offered to study the role hypothalamic leptin resistance in control of neuron activity, body weight, feeding behavior and metabolic homeostasis obesity. The interested candidates can check our publications in this area to understand the research interests of our lab better:. 2009 Jan 7;9:35-51. Endoplasmic reticulum stress plays a central role in development of leptin resistance. Liu J et al.

. 2016 Sep;22:1023-32. Withaferin A is a leptin sensitizer with strong antidiabetic properties in mice. Feng X, et al.,2019 March 4-Online publication. IL1R1 is required for celastrol’s leptin-sensitization and antiobesity effects. Guan D, et al.,, 2024. Central Inhibition of HDAC6 re-sensitizes leptin signaling during obesity to induce profound weight loss.

The ideal candidates for both positions should have a Ph.D., M.D. or M.D./Ph.D. degrees with strong experience in neuroscience, molecular biology and technical skills to perform intracranial injections evident by peer-reviewed publications in reputable journals. These positions will also include anti-obesity drug development and will provide the fellows opportunity to also learn early drug discovery and development approaches.

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