Largest study of BRCA1 and BRCA2 carriers refines cancer risk estimates in Asian population

Apr 26 2024SingHealth A team of clinician-scientists and scientists from the University of Nottingham , National Cancer Centre Singapore , Cancer Research Malaysia, Nanyang Technological University, Singapore , University of Malaya, University of Cambridge, A*STAR's Genome Institute of Singapore and other institutions, have conducted the largest study done to date of BRCA1 and BRCA2 carriers in an Asian population and refined breast and ovarian cancer risk estimates for this population.

To address this pressing clinical need, a multidisciplinary team of clinician-scientists, scientists and genetic counselors, studied the clinical data of 572 families in Singapore and Malaysia with BRCA1 and BRCA2 mutations. The family members were 20 to 79 years old and of Chinese, Indian and Malay ethnicity. Of the 1,121 BRCA1 carriers, 144 and 65 were diagnosed with breast and ovarian cancer, respectively.

The cumulative risks of Chinese BRCA1 and BRCA2 carriers in Singapore developing breast and ovarian cancers were similar to Asians in the United States but higher compared to Chinese in Malaysia. The cumulative risks of Indian BRCA1 and BRCA2 carriers in Singapore were similar to Asians in UK but higher compared to Indians from Malaysia.

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