Minibrains grown in the lab may help explain why concussions and other traumatic brain injuries raise people's risk of dementia.
The cerebral organoids used in the study looked like pinhead-sized clumps of brain cells, rather than perfectly miniaturized versions of full-size human brains. That said, organoids capture aspects of human biology that are difficult to study in animals, like lab mice. They can also be grown to include specific types of cells from different regions of the brain, arranged in layers as they would be in a person's head.
By submitting your information you agree to the Terms & Conditions and Privacy Policy and are aged 16 or over.In addition, the team saw changes in a protein called TDP-43, which has been tied to both TBIs and many neurodegenerative diseases in the past. The protein, typically found corralled in the nucleus of healthy cells, is involved in controlling how instructions in DNA are used to make proteins. But in neurodegenerative conditions, TDP-43 accumulates in clumps.
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