Researchers develop precise drugs to target HIV's Nef protein

Mar 9 2024University of Michigan

With most viruses, when people get infected, they get sick for a while and then the immune system kicks in and the virus is cleared. But with HIV, once a patient is infected, that virus will persist for their entire life-;meaning they must remain on treatments indefinitely." One key to HIV's ability to remain hidden in patients' cells is a protein that the virus makes, called Nef.

Another major challenge with developing CMA as an anti-HIV drug is that Nef is not CMA's primary target. Collins' lab team ran the new compounds through a battery of tests to measure their toxicity to cells, as well as how they affected the activities of both HIV Nef and V-ATPase.

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