Scientists have made a stem cell breakthrough in elephants, which could mean researchers are one step closer to bringing back long-extinct woolly mammoths, the de-extinction company Colossal Biosciences has announced.
iPSCs also open a path to creating elephant sperm and egg cells, which are essential for mammoth de-extinction, in the lab. With fewer than 52,000 Asian elephants left in the wild, according to WWF, harvesting cells from these animals would prove difficult and undesirable. "One of the things that we had to overcome for elephant cells is that they do have this expansive TP53 pathway," Hysolli said."We had to suppress this pathway via two means in order to get these iPSCs, so we had to go through a multistep process in order to achieve them."
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