Researchers introduce a pioneering approach to combat neurodegenerative diseases

Feb 16 2024Northwestern University Researchers led by Northwestern University and the University of Wisconsin-Madison have introduced a pioneering approach aimed at combating neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and Amyotrophic lateral sclerosis .

The study focuses on disrupting the Keap1/Nrf2 protein-protein interaction , which plays a role in the body's antioxidant response. By preventing the degradation of Nrf2 through selective inhibition of its interaction with Keap1, the research holds promise for mitigating the cellular damage that underlies these debilitating conditions.

The study introduces an innovative solution: protein-like polymers, or PLPs, are high-density brush macromolecular architectures synthesized via the ring-opening metathesis polymerization of norbornenyl-peptide-based monomers. These globular, proteomimetic structures display bioactive peptide side chains that can penetrate cell membranes, exhibit remarkable stability and resist proteolysis.

Focusing on the challenge of activating processes crucial for the body's antioxidant response, the team's research offers a novel solution. The team provides a robust, selective method enabling enhanced cellular protection and offering a promising therapeutic strategy for a range of diseases including neurodegenerative conditions.

Related StoriesThis approach not only represents a significant advance in targeting transcription factors and disordered proteins, but also showcases the PLP technology's versatility and potential to revolutionize the development of therapeutics. The technology's modularity and efficacy in inhibiting the Keap1/Nrf2 interaction underscore its potential for impact as a therapeutic, but also as a tool for studying the biochemistry of these processes.

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