A $5 million grant from the National Institutes of Health will create a network of brain tissue research at UIC, Northwestern University, Lurie Children's Hospital, Rush University and University of Chicago. The institutions will utilize a data platform developed at UIC called INTUITION that combines tissue data with clinical, functional, genetic and 3D imaging information to assist clinicians treating patients and help researchers better understand the mechanisms of brain disorders.
In 2017, UIC launched a NeuroRepository to collect and preserve brain tissue surgically removed from patients to treat epilepsy or taken in tumor biopsies. But gathering this valuable tissue is only one piece of the puzzle. To maximize the clinical and research potential, insights from studying the tissue itself must be combined with 3D images and electrical measurements of brain activity, clinical records on the patients' history and symptoms and data on genetics and other cellular factors.
To ensure the consistency of the data across sites, the project will include educational training to coordinate and standardize procedures for tissue collection and data processing at each location. The INTUITION platform also will be modified to allow federated data sharing -; a computational method where researchers can securely query de-identified data stored by different institutions while protecting patient privacy.
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