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Doctors improve antioxidant response in diabetics and hypertensive patients

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RUDN University doctors studied what happens to oxidative and antioxidant processes in the heart during diabetes and hypertension. The work provides insight into the relationship between these processes at the molecular level and outlines possible therapeutic targets. The results were published in Pathophysiology.

. Normally, ROS constantly present in cell metabolism and perform several functions, including the regulation of the myocardium, the muscle tissue of the heart. However, excessive amounts of ROS damage healthy tissues through oxidation and damage all cell components. Thioredoxin-interacting protein is a key regulator of oxidative stress.

"A large amount of data has already been accumulated that describes the participation of TXNIP and GS in the response to pathological factors of various diseases. But despite this, we do not have a clear understanding of their role in the pathogenesis of myocardial damage caused by a combination of hypertension and"Our goal was to investigate the features of the expression of TXNIP and GS in the myocardium with these pathologies," said Anastasia Sklifasovskaya, Ph.D.

It turned out that the level of TXNIP increases in rats with hypertensive crises at the age of 57 weeks, in rats of all age groups with diabetes, and in the group with a combination of diseases. The same animals showed almost a two-fold increase in GS. Moreover, in younger rats with hypertensive crises, the level of TXNIP is significantly reduced.

 

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