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Medical researchers tackle immune rejection of biomedical implants

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To learn more about what causes the body to reject biomedical implants, a team at the University of Arizona College of Medicine-Tucson identified a protein that appears to help drive this response, and hopes their discoveries will improve the design and safety of biomedical implants. The findings were published today in Nature Biomedical Engineering.

Biomedical implants, such as breast implants, pacemakers and orthopedic hardware, have transformed medicine, but a significant number are rejected by the body and must be removed. The culprit is a little-understood immune reaction called foreign body response, or FBR, in which the body encapsulates the implant in scar tissue.

"When we examined the severe fibrotic samples, RAC2 was one of the most important proteins we found," Chen said."Because it seemed to drive a lot of downstream pathways, we decided to explore a little more closely." "We believe that local targeted therapy is better. Maybe there are ways to conjugate this drug onto an implant with some sort of coating to minimize systemic problems," Gurtner said.

 

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