Natural killer cells are a type of white blood cell that play a crucial role in the body’s immune system. They specialize in detecting and destroying cells that are infected by viruses or have become cancerous. Unlike other immune cells, NK cells can act without prior exposure to the target cell, making them a vital first line of defense against new threats.
of the Chinese Academy of Sciences , working alongside Prof. Zhang Zemin from Peking University, have illustrated the variations in natural killer cells across different cancer types and tissues. They identified a specific subgroup of NK cells that demonstrate abnormal anti-tumor functions that thrive specifically within the tumor microenvironment.
Over the years, Prof. Tian and Prof. Peng’s team have been studying the heterogeneity of NK cells across different tissues. In this study, the researchers collected an extensive dataset of single-cell transcriptomes, encompassing 24 cancer types and including a total of 1,223 samples from 716 patients and 47 healthy individuals. They identified five distinct subtypes of CD56
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