Nuvectis, which focuses on the development of innovative precision medicines for the treatment of serious conditions of unmet medical need in oncology, has launched a Phase 1a dose escalation clinical trial of NXP900 in the US.
SFKs are aberrantly activated in various cancer types and they are central mediators of various oncogenic processes such as proliferation, survival, cell adhesion, invasion, and angiogenesis. NXP900 is a potent and highly selective SFK inhibitor, including low nanomolar IC50 against YES1 and SRC that demonstrated robust single agent anti-cancer activity against several solid tumor types in preclinical models.
Related Stories“This is a great step towards a medicine that could treat some of the toughest cancers and extend the lives of many thousands of people.”“To know a drug discovered and developed preclinically in our lab is now to be given to patients is extremely rewarding – it is the realization of years of work, collaboration and ambition.”
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