Currently identified RNA modifications are modulated by the"writing-erasing-reading" system, which consists of various RNA modifying enzymes functioning as"writers,""erasers" and"readers." In a complete process of RNA modification,"writer" installs RNA modifications on RNA substrates;"eraser" removes the chemical marks installed on RNA;"reader" recognizes the RNA modifications and guides the fate of target RNAs.
Based on the RNA modification regulatory system, Qiu and Jing comprehensively summarized the functional involvement of the seven RNA modifications in five human disease models, including cancer, neurological disorders, cardiovascular disease,a. 18097 inhibits FTO to promote substrate mRNAs m6A level in breast cancer. b. HUHS015 disturbs ALKBH3 functioning as prostate cancer antigen 1. c. R-2HG prevents FTO removing m6A from MYC/CEBPα in AML. d.