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Early findings suggest clinical and lab-based approach critical to tracking head and neck cancer recurrence

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Early findings of two studies from the University of Michigan Rogel Cancer Center shed light on new ways to anticipate recurrence in HPV-positive head and neck cancer sooner. The papers, published in Cancer and Oral Oncology, offer clinical and technological perspectives on how to measure if recurrence is happening earlier than current blood tests allow, and provide a framework for a new, more sensitive blood test that could help in this monitoring.

and can be disfiguring, interfering with the ability to talk, swallow, and even breathe," said Paul Swiecicki, M.D., associate medical director for the Oncology Clinical Trials Support Unit at Rogel."As of now, there's no test to monitor for its recurrence except watching for symptoms or potentially using aaims to identify different clinical ways that providers can more strategically track for recurrence.

Patients with HPV-positive cancers were found to develop recurrent disease significantly later than those that were HPV-negative, and also were more likely to spread to the lungs. Taken together, these characteristics may help create a"surveillance" method in the future that combines routineSwiecicki is quick to mention that, at this point, the results of this study are largely theoretical and provide a helpful framework to direct further research.

Not only is this test more sensitive and able to detect a smaller number of DNA fragments in blood, but it's innovative in other ways too, says Chandan Bhambhani, Ph.D., the first author of the study."We achieved this level of sensitivity by looking for nine different pieces of the HPV genome DNA all at once," said Bhambhani, research lab specialist.

 

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