New study may shed light on how parasite strain diversity can impact Chagas disease progression

Chagas, a lesser-known and studied tropical disease, is caused by Trypanosoma cruzi parasites, which are transmitted by kissing bugs. In the Americas, the disease affects 6 million people in 21 countries, with approximately 30,000 new cases each year. While most infected patients remain asymptomatic, about 20-40 percent of those infected will develop chronic heart disease years or decades after infection, and about 5 percent will develop digestive disease.

Since the 1980s, researchers have proposed that different strains could be associated with different disease outcomes due to the parasite's genetic diversity, but decades of research failed to uncover clear associations. In finding a clear association, these results provide a new framework for the development of more effective treatments and vaccines."

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