Reviewed by Danielle Ellis, B.Sc.Aug 18 2023 In this study, they compared the pathology with that of humans, and suggested the importance of Japanese squirrels in the comparative pathological analysis of fibrinogen Aα-chain amyloidosis.Amyloidosis is a disease group in which amyloid, generated by misfolding of host proteins, deposits in several organs.
They performed mass spectrometry-based proteomic analysis and immunohistochemistry, and identified fibrinogen Aα-chain as a precursor protein. "Interestingly, amyloid exclusively deposited in the glomeruli but not in the tubulointerstitium in the affected kidney, which is same as the human condition," said Iwaide.
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