How a Canadian scientist and a venomous lizard helped pave the way for Ozempic - National | Globalnews.ca

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'In the 1990s there were no gene banks, you couldn’t look stuff up online and you actually had to clone stuff, and in order to do that we had to get lizard DNA.'

'Silver bullet for dealing with diabetes'

Murphy then contacted the Utah Zoo, known for its expertise in lizard breeding, asking about the possibility of getting one for research.“I put out the call to the zoo and said, ‘Hey, there may be the silver bullet for dealing with diabetes’ and they came back and said yes.”The Gila monster was flown into Toronto Pearson Airport and Murphy picked up the lizard, adding that although it is venomous, he had “handled things far more dangerous.

“Despite all the pharmaceutical companies in the world trying to develop a GLP-1-like drug, this lizard venom peptide became the first approved for the treatment of Type 2 diabetes anywhere in the world, and it was approved on April 28th, 2005,” Drucker said.Subsequently, a new generation of GLP-based drugs emerged that lasted even longer.The most popular example of these advancements is Ozempic, a GLP-based drug that surpassed its predecessors.

“Dr. Drucker’s research is cited in the publication outlining the discovery of once-weekly semaglutide ,” the spokesperson said.Because there is a short supply of Ozempic, he said he believes it should be used for people with health problems, and not for “casual weight loss.”, the most common side effects include nausea, vomiting, diarrhea, constipation and abdominal pain.

 

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