Researchers shed light on role of Tip60 enzyme in genetic disruptions that cause Alzheimer's disease

to generate different functional variants of the same protein using a process known as alternative RNA splicing.

The team led by Akanksha Bhatnagar, a Ph.D. student, and Felice Elefant, Ph.D., a professor, who are biology researchers in Drexel's College of Arts and Sciences, is the first to uncover the role of the Tip60 enzyme in binding to certain RNA in the brain to control how they are spliced. "We have previously shown that Tip60 enzyme levels are depleted in Alzheimer's disease brains and this depletion results in some genes getting inactivated. However, with this new RNA splicing function, we now show Tip60 is also not present to bind to the RNA to allow for appropriate splicing in the brain and may be causing some of the splicing defects observed in Alzheimer's disease," said Elefant.

Education Education Latest News, Education Education Headlines

Similar News:You can also read news stories similar to this one that we have collected from other news sources.

Researchers identify novel genes that may increase risk for schizophreniaResearchers have identified two previously unknown genes linked to schizophrenia and newly implicated a third gene as carrying risk for both schizophrenia and autism. Led by the Icahn School of Medicine at Mount Sinai, the multi-center study further demonstrated that the schizophrenia risk conferred by these rare damaging variants is conserved across ethnicities. The study may also point to new therapeutics.
Source: medical_xpress - 🏆 101. / 51 Read more »