UP researchers discover gene links breast cancer, stress, irregular sleep

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Researchers from the University of the Philippines Diliman find that gene Krüppel-like factor 9 functions to suppress tumor growth, and links the effects of stress, an irregular body clock, and breast cancer.

in breast tumors compared to normal breast tissue. This means the gene becomes less responsive due to a decrease in receptors on the cell surface.

In normal body function, the circadian cycle, which involves a regular 24-hour pattern of biological activity, is mainly controlled by the 12-hour light-dark cycle. This regulates several bodily functions, like the sleep-wake cycle, digestion, and the release and suppression of various hormones at certain times of the day.

While the gene is present in both men and women, they found that KLF9 antagonizes estrogen action. It means that while breast incidents in men are only less than 1%, trans women may increase their risk for breast cancer, although lower than cisgender women, due to the increase of estrogen in their bodies.

“Health should be a priority and should never be compromised, but nowadays, it’s really hard to balance healthy living habits and daily living norms,” said Lois Gaspar, who works the graveyard shift in the banking industry and lives with Polycystic Ovary Syndrome ., a hormonal imbalance problem for women, reducing stress and balancing their circadian rhythm are vital for their health.

This night differential, however, is different from hazard pay, which is “an additional compensation for performing hazardous duties and for enduring physical hardships in the course of performance of duties,” as described by the Department of Budget and Management.

 

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UP research: Gene links breast cancer to stress, changes in light-dark cycles | BusinessMirrorNew research from the University of the Philippines Diliman-College of Science has found a conclusive link between stress, altered light-dark cycles—such as in the cases of night shift workers and frequent international travelers—and breast cancer, said a UPD-CS news release. Molecular biologist Dr. Pia Bagamasbad and her student, Weand Ybañez,…
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