In a study with over 5,000 people, UT Health San Antonio researchers found 21 genes, known to play a role in Alzheimer’s, were vulnerable to the disease when the person had a high BMI or high hip-to-waist ratio.
“Obesity could change some internal functions in the body that will exacerbate any process or just contribute to an ongoing damaging process leading to dementia,” Satizabal said. “There are several hypotheses, just perhaps because, you know, in obesity, there’s some metabolic dysregulation.” “The prevalence of Alzheimer’s disease is projected to explode in the next couple of decades. And obesity also has been steadily increasing worldwide. And if obesity is a risk factor for Alzheimer’s disease, imagine what is going to happen in a couple of decades if we don’t do anything about it now,” Satizabal said.
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