Obesity is a growing health concern worldwide and is defined as an excessive accumulation of body fat that can have negative impacts on health. Obesity can lead to various health problems including cardiovascular disease, type 2 diabetes, certain types of cancer, sleep apnea, and joint problems.
Haas and her team observed in an earlier study that when mice become obese, females grow a lot of new blood vessels to supply the expanding fat tissue with oxygen and nutrients, whereas males grow a lot less. In this latest study published in, Haas and her co-authors, including York Ph.D.
“It is exciting to observe the continuing resilience that female endothelial cells display even when stressed by a long-term high-fat diet,” Pislaru says. “The findings from our study can help researchers to get a better understanding of why obesity manifests differently in men and women.” Female endothelial cells replicated faster, while male endothelial cells displayed greater sensitivity to an inflammatory stimulus. By comparing with previously published data sets, the researchers found endothelial cells from aged male mice also displayed a more inflammatory profile compared to female cells.
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