Scientists Discover a Unique Gut Bacteria That May Cause Arthritis

Rheumatoid arthritis is an autoimmune and inflammatory disease that causes joint inflammation and pain.

A group of researchers from the Division of Rheumatology worked on the study under the leadership of Kristine Kuhn, MD, Ph.D., an associate professor of rheumatology. The study was recently published in the journal. Meagan Chriswell, a medical student at CU, is the paper’s lead author. The researchers employed animal models to host the newly found bacteria in order to explore their theory further. These tests revealed that the bacteria not only caused the animal models to develop the blood markers observed in people who are at risk for RA but that some of the models also developed full-blown RA.

“The next thing we want to do is identify, in larger populations of individuals at risk for RA, if these bacteria correlate with other genetic, environmental, and mucosal immune responses, and then ultimately, the development of RA,” Kuhn says. “Then we could say, ‘This is a marker that’s useful in helping predict who will go on to develop RA,’ and apply prevention strategies.

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