in adulthood mirror those of humans — are important models with which to test interventions that can restore form and function. In new research, a team of scientists at Tufts University demonstrated long-term regrowth, marked tissue repatterning, and functional restoration of an amputatedhindlimb following a 24-hour exposure to a five-drug cocktail delivered by a silicone wearable bioreactor.
The authors triggered the regenerative process in African clawed frogs by enclosing the wound in a wearable bioreactor containing silk protein infused with five small-molecule compounds. The researchers observed dramatic growth of tissue in many of the treated frogs, re-creating an almost fully functional leg.
Twenty-four-hour multidrug treatment delivered by bioreactor improves repatterning in regenerates. Image credit: Murugan“It’s exciting to see that the drugs we selected were helping to create an almost complete limb,” Dr. Murugan said. Within the first few days after treatment, they detected the activation of known molecular pathways that are normally used in a developing embryo to help the body take shape.
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