The miracle that two Canadians gave the world 100 years ago is still saving lives

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The miracle that two Canadians gave the world 100 years ago is still saving lives. 💉

A hundred years ago, almost to the day, Dr. Frederick Banting celebrated his 30th birthday in a memorable way.

“Even globally, it was a major deal at the time,” says Christopher Rutty, a professional medical and public historian and adjunct professor at the University of Toronto’s Dalla Lana School of Public Health. “And one reason we still talk about it today is that, as a friend of mine, Grant Maltman, the curator of Banting House in London, says, ‘Today, we have better insulin, but nothing better than insulin.

It’s not a cure, though, as Banting and Best cautioned from the outset. A century later, a cure is still elusive and the problem itself has changed significantly. Now most cases are type 2 diabetes. At the time of insulin’s discovery, not only would type 1 have been predominant, there was no understanding that there was a difference between type 1 and type 2.

“If we have chronically elevated stress hormones, this can increase and promote high levels of blood sugars and, over time, that can put stress on the pancreas and cause insulin resistance in the liver, and in the muscle and in the adipose tissue,” she explained. “And all those things combined can then lead to beta cell dysfunction, which can lead to an increased risk for type 2 diabetes.”

Because there are often no symptoms, all pregnant women are carefully screened for elevated glucose levels. If they go high enough to be considered a danger, they are given glucose-lowering drugs. After the delivery, though, new parents and even some family care physicians lose sight of the fact that this is an early warning sign. Women who experience gestational diabetes are seven to 10 times more likely to develop type 2 diabetes in the future.

 

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